The world faces unprecedented grand challenges of which the recent Covid-19 pandemic is just one pertinent example. Innovation is crucial for addressing these grand challenges and business is an important source of innovation and needs to be integrated. However, to harness the full potential of innovation in addressing grand challenges, the resulting novel products or services need to be subject to a responsible innovation process. In a series of recent articles (in 2020, 2017 and 2019), we have worked on the idea of responsible innovation. We have proposed an understanding of responsible innovation consisting of three types of responsibility: (1) the responsibility to do no harm, (2) the responsibility to do good, and (3) responsible go