Given the scale and severity of the Covid-19 crisis, companies of all sizes and operating in all contexts are now faced with a range of unprecedented challenges that will require clarity of thinking, sharp focus on goals, the need to think outside the box, commitment to adhere to international standards and norms, and a concerted effort of collective action. Survival of companies is important, but that is a sub-set of the survival of our common humanity. Companies have the responsibility to respect the human rights of all workers directly employed by them, and they should use their leverage to safeguard the rights of those who work for their suppliers, partners, and associates. Beyond that, companies have responsibilities to communities directly affected by them, and users and consumers of their goods and services. They should also look ahead to issues such as how the products they make and services they offer can adapt to meet critical urgent and future needs, support relief efforts, contribute to research, and explore other positive ways to augment public dialogue on long-term planning to prevent the recurrence of such a crisis so that we are collectively more resilient in future.