This issue brief outlines the macrotrends and disruptions that could shape the environment business operates in over the next 10 years. These represent major shifts in the demographic, environmental, economic, technological, political and cultural landscapes that can be foreseen with a relatively high degree of certainty, though their implications are often more uncertain or ambiguous. We then focus in on a subset of the macrotrends to explore this ambiguity and suggest how the global business community might seek to influence the way these trends play out in order to accelerate progress on Vision 2050.